NME1 Recombinant Protein (OPCD05684)

Catalog No: OPCD05684

NME1 Recombinant Protein (OPCD05684) using SDS-PAGE

NME1 Recombinant Protein (OPCD05684) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Glu152
  Subcellular Location: Nucleus, Cytoplasm
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: NME1
• Gene Full Name: NME/NM23 nucleoside diphosphate kinase 1
• Alias Symbols: AWD;epididymis secretory sperm binding protein;GAAD;granzyme A-activated DNase;metastasis inhibition factor nm23;NB;NBS;NDKA;NDP kinase A;NDPKA;NDPK-A;NM23;NM23-H1;non-metastatic cells 1, protein (NM23A) expressed in;nucleoside diphosphate kinase A;tumor metastatic process-associated protein.
• NCBI Gene Id: 4830
• Protein Name: Nucleoside diphosphate kinase A
• Description of Target: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
• Uniprot ID: P15531
• Protein Accession #: NP_000260.1
• Nucleotide Accession #: NM_000269.2
• Protein Size (# AA): Met1~Glu152
• Molecular Weight: 22kDa