NME1 Antibody - N-terminal region : FITC (AVARP00009_P050-FITC)

Catalog No: AVARP00009_P050-FITC

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: DB, IHC, WB
• Additional Information: IHC Information: Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma tissue using anti-Nm23-H1 antibody (AVARP00009_P050).
  IHC Information: Pancreas
  IHC Information: Small intestine
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NME1
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: ANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEH
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-NME1 (AVARP00009_P050-FITC) antibody is Catalog # AAP30457 (Previous Catalog # AAPP01041)
• Reference: Liu,S.J., (2008) Br. J. Cancer 98 (2), 363-369

Target Info

• Gene Symbol: NME1
• Gene Full Name: Non-metastatic cells 1, protein (NM23A) expressed in
• Alias Symbols: NB, AWD, NBS, GAAD, NDKA, NM23, NDPKA, NDPK-A, NM23-H1
• NCBI Gene Id: 4830
• Protein Name: Nucleoside diphosphate kinase B
• Description of Target: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
• Uniprot ID: P22392
• Protein Accession #: NP_000260
• Nucleotide Accession #: NM_000269
• Protein Size (# AA): 152
• Molecular Weight: 17kDa
• Protein Interactions: SREK1IP1; PID1; TNPO2; POLR1C; NME4; NME3; NME1; TUBG1; UBC; MDM2; ASB18; BMI1; CHRAC1; NME1-NME2; WDR1; THOP1; SORD; RBBP7; OXCT1; IDH1; FDPS; MAPK14; FBXO6; WDYHV1; NIF3L1; SOX30; FXR2; SMARCD1; NME2; CCND3; UROD; SOD1; MIF; ERG; EBNA-LP; HDAC5; STRAP;