Catalog No: OAED00344
Size:100UG
Price: $409.00
SKU
OAED00344
Availability: Domestic: within 1-2 week delivery | International: 1-2 week
Bulk
Order
Aviva's
Satisfaction
Guarantee
Contact Us:
Shipping Info:
  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.
Datasheets/ManualsPrintable datasheet for NLRP1 Antibody (OAED00344) (OAED00344)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid PBS containing 0.02% sodium azide.
ClonalityMonoclonal
CloneNalpy1-4
IsotypeIgG1
HostMouse
ApplicationImmunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Reconstitution and StorageAfter opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Stable for at least one year after receipt when stored at -20°C. Short Term Storage: 4°C
Long Term Storage: -20°C.
ImmunogenRecombinant human NLRP1/NALP1 (NACHT-, LRR- and PYD-containing protein 1) (pyrin domain).
Concentration1 mg/ml
SpecificityRecognizes the pyrin domain (PYD) of human NLRP1/NALP1. Does not cross-react with mouse NLRP1/NALP1.
SourcePurified from concentrated hybridoma tissue culture supernatant.
Application InfoICC: 1:1000
IHC (paraffin sections, microwave treatment)WB: 1:1000. Optimal conditions must be determined individually for each application.
ReferenceInflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response: J.A. Kummer, et al.; J. Histochem. Cytochem. 55, 443 (2007), Abstract;
Gene SymbolNLRP1
Gene Full NameNLR family pyrin domain containing 1
Alias SymbolsAIADK;CARD7;caspase recruitment domain protein 7;caspase recruitment domain-containing protein 7;CIDED;CLR17.1;death effector filament-forming Ced-4-like apoptosis protein;DEFCAP;DEFCAP-L/S;JRRP;MSPC;NAC;NACHT, leucine rich repeat and PYD (pyrin domain) containing 1;NACHT, leucine rich repeat and PYD containing 1;NACHT, LRR and PYD containing protein 1;NACHT, LRR and PYD domains-containing protein 1;NALP1;nucleotide-binding domain and caspase recruitment domain;nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1;PP1044;SLEV1;VAMAS1.
NCBI Gene Id22861
Protein NameNACHT, LRR and PYD domains-containing protein 1
Description of TargetAs the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).
Uniprot IDQ9C000
Protein Accession #NP_001028225.1; NP_055737.1; NP_127497.1; NP_127499.1; NP_127500.1
Nucleotide Accession #NM_001033053.2; NM_014922.4; NM_033004.3; NM_033006.3; NM_033007.3
  1. What is the species homology for "NLRP1 Antibody (OAED00344)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "NLRP1 Antibody (OAED00344)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 week".

  3. What buffer format is "NLRP1 Antibody (OAED00344)" provided in?

    This item is provided in "Liquid PBS containing 0.02% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "NLRP1 Antibody (OAED00344)"?

    This target may also be called "AIADK;CARD7;caspase recruitment domain protein 7;caspase recruitment domain-containing protein 7;CIDED;CLR17.1;death effector filament-forming Ced-4-like apoptosis protein;DEFCAP;DEFCAP-L/S;JRRP;MSPC;NAC;NACHT, leucine rich repeat and PYD (pyrin domain) containing 1;NACHT, leucine rich repeat and PYD containing 1;NACHT, LRR and PYD containing protein 1;NACHT, LRR and PYD domains-containing protein 1;NALP1;nucleotide-binding domain and caspase recruitment domain;nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1;PP1044;SLEV1;VAMAS1." in publications.

  5. What is the shipping cost for "NLRP1 Antibody (OAED00344)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "NLRP1 Antibody (OAED00344)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "NLRP1 Antibody (OAED00344)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "NLRP1 Antibody (OAED00344)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "NLRP1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "NLRP1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "NLRP1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "NLRP1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "NLRP1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "NLRP1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

Write Your Own Review
You're reviewing:NLRP1 Antibody (OAED00344)
Your Rating
We found other products you might like!