Catalog No: OAPB00186 (Formerly GWB-4099E8)
Size:100UG
Price: $461.00
SKU
OAPB00186
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for NLRC4 Antibody (OAPB00186) (OAPB00186)
Product Info
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLiquid. Ipaf Antibody is supplied in PBS containing 0.02% sodium azide.
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot
::Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and StorageIpaf antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ImmunogenIpaf antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human Ipaf. The immunogen is located within the last 50 amino acids of Ipaf.
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceHuman
Concentration1 mg/ml
Blocking PeptideFor anti-NLRC4 (OAPB00186) antibody is Catalog # OEPB02282
Application InfoIpaf polyclonal antibody can be used for the detection of Ipaf by Western blot at 0.5 to 2 ug/ml. Human peripheral blood leukocyte (PBL) cell lysate can be used as positive control and a 110 kDa band can be detected. Ipaf antibody is human specific. (Optimal dilution should be determined by user)
ReferenceLi P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91:479-89.;Poyet J-L, Srinivaula SM, Tnani M, et al. Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J. Biol. Chem. 2001; 276:28309-13.;Geddes BJ, Wang L, Huang WJ, et al. Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. Biochem. Biophys. Res. Commun. 2001; 284:77-82.;
Gene SymbolNLRC4
Gene Full NameNLR family CARD domain containing 4
Alias SymbolsAIFEC;CARD, LRR, and NACHT-containing protein;CARD12;caspase recruitment domain family, member 12;caspase recruitment domain-containing protein 12;CED-4-like protein Clan;CLAN;CLAN1;CLANA;CLANB;CLANC;CLAND;CLR2.1;FCAS4;Ice protease-activating factor;ICE-protease activating factor;IPAF;NLR family CARD domain-containing protein 4;NOD-like receptor C4;nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4.
NCBI Gene Id58484
Protein NameNLR family CARD domain-containing protein 4|NLR family CARD domain-containing protein 4 isoform a [Homo sapiens]
Description of TargetKey component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).
Uniprot IDQ9NPP4
Protein Accession #https://www.ncbi.nlm.nih.gov/protein/NP_067032
Nucleotide Accession #NM_001199138.1; NM_001199139.1; NM_001302504.1; NM_021209.4
Molecular Weight110 kDa
  1. What is the species homology for "NLRC4 Antibody (OAPB00186)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "NLRC4 Antibody (OAPB00186)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "NLRC4 Antibody (OAPB00186)" provided in?

    This item is provided in "Liquid. Ipaf Antibody is supplied in PBS containing 0.02% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "NLRC4 Antibody (OAPB00186)"?

    This target may also be called "AIFEC;CARD, LRR, and NACHT-containing protein;CARD12;caspase recruitment domain family, member 12;caspase recruitment domain-containing protein 12;CED-4-like protein Clan;CLAN;CLAN1;CLANA;CLANB;CLANC;CLAND;CLR2.1;FCAS4;Ice protease-activating factor;ICE-protease activating factor;IPAF;NLR family CARD domain-containing protein 4;NOD-like receptor C4;nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4." in publications.

  5. What is the shipping cost for "NLRC4 Antibody (OAPB00186)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "NLRC4 Antibody (OAPB00186)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "NLRC4 Antibody (OAPB00186)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "110 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "NLRC4 Antibody (OAPB00186)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "NLRC4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "NLRC4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "NLRC4"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "NLRC4"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "NLRC4"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "NLRC4"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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