Nitazoxanide (OOMC00080)

Catalog No: OOMC00080

Product Info

• Product Format: Powder
• Additional Information: CAS: 55981-09-4
  Molecular Formula: C12H9N3O5S
  Chemical Name: O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate
  Primary Activity: Antiviral, antiparasitic
  COVID-19 Rationale: Inhibits the SARS-CoV-2 at low-micromolar concentration
• Reconstitution and Storage: Soluble in DMSO (up to at least 50 mg/ml). Store at -20C.
• Purity: > 98%
• Reference: 1) White (2004) Nitazoxanide: a new broad spectrum antiparasitic agent; Expert Rev. Anti. Infect. Ther. 2 43 2) Rossignol (2014) Nitazoxanide: a first-in-class broad-spectrum antiviral agent; Antiviral Res. 110 94 3) Hoffman et al. (2007) Antiparasitic Drug Nitazoxanide Inhibits the Pyruvate Oxidoreductases of Helicobacter pylori, Selected anaerobic Bacteria and Parasites, and Campylobacter jejuni; Antimicrob. Agents Chemother. 51 868 4) Elazar et al. (2009), The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation; Gastorenterology 137 1827 5) Qu et al. (2018), Small molecule promotes b-catenin citrullination and inhibits Wnt signaling in cancer; Nat. Chem. Biol. 14 94

Target Info

• Molecular Weight: 307.28 g/mol