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- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
| Datasheets/Manuals | Printable datasheet for NIPBL Antibody (OACA10589) (OACA10589) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Human Nipped-B-like protein (2523-2697AA) |
| Purification | Protein G Purified |
| Preservative | 0.03% Proclin 300 |
| Formulation | 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purity | >95% |
| Gene Symbol | NIPBL |
|---|---|
| Gene Full Name | NIPBL cohesin loading factor |
| Alias Symbols | CDLS;CDLS1;delangin;IDN3;IDN3-B;Nipped-B homolog;nipped-B-like protein;Scc2;SCC2 homolog;sister chromatid cohesion 2 homolog. |
| NCBI Gene Id | 25836 |
| Protein Name | Nipped-B-like protein |
| Description of Target | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). |
| Uniprot ID | Q6KC79 |
| Protein Accession # | NP_056199 |
| Nucleotide Accession # | NM_015384 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "NIPBL Antibody (OACA10589)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "NIPBL Antibody (OACA10589)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "NIPBL Antibody (OACA10589)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "NIPBL Antibody (OACA10589)"?
This target may also be called "CDLS;CDLS1;delangin;IDN3;IDN3-B;Nipped-B homolog;nipped-B-like protein;Scc2;SCC2 homolog;sister chromatid cohesion 2 homolog." in publications.
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What is the shipping cost for "NIPBL Antibody (OACA10589)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "NIPBL Antibody (OACA10589)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "NIPBL Antibody (OACA10589)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "NIPBL Antibody (OACA10589)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "NIPBL"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "NIPBL"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "NIPBL"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "NIPBL"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "NIPBL"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "NIPBL"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.