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Catalog No: ATM00002-100UG
Price: $499.00
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NFKB1 p50 Recombinant Antibody [8M5M] (ATM00002)

Datasheets/ManualsPrintable datasheet for NFKB1 p50 Recombinant Antibody [8M5M] (ATM00002)
Product Info
ClonalityRecombinant Monoclonal
Additional InformationThis product was developed using Active Motif’s AbFlex® antibody technology.
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenRecombinant Human NFKB1 p50 aa245-433
PurificationProtein A
Concentration1 mg/mL
Gene SymbolNFKB1 p50
Gene Full Namenuclear factor kappa B subunit 1
Alias SymbolsKBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta
NCBI Gene Id4790
Protein NameNuclear factor NF-kappa-B p50 subunit
Description of TargetThis gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
Uniprot IDP19838-1
Molecular Weight47.5 kDa
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