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NFKB1 Antibody (OACA02427)

100 ug
$315.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB, IHC, CHIP
Reconstitution and Storage:
Store at 4C for up to one month. For long term storage, aliquot and store at -20C or -80C. Avoid freeze thaw cycles.
Replacement Item:
This antibody may replace item sc-114, HPA027305
Immunogen:
Recombinant human Nuclear factor NF-kappa-B p105 subunit protein
Purification:
Caprylic Acid Ammonium Sulfate Precipitation purified
Predicted Homology Based on Immunogen Sequence:
Human
Datasheets/Manuals:
Printable datasheet for anti-NFKB1 (OACA02427) antibody
Specificity:
Human
Formulation:
Provided in PBS, pH 7.4, 50% Glycerol, 0.03% Proclin 300
Target Reference:
[1] The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product. Kieran M., Blank V., Logeat F., Vandekerckhove J., Lottspeich F., le Bail O., Urban M.B., Kourilsky P., Baeuerle P.A., Israel A.Cell 62:1007.
Gene Symbol:
NFKB1
Official Gene Full Name:
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Alias Symbols:
p50, KBF1, p105, EBP-1, CVID12, NF-kB1, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B
NCBI Gene Id:
4790
Protein Name:
nuclear factor NF-kappa-B p105 subunit
Description of Target:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
Swissprot Id:
P19838
Protein Accession #:
NP_001158884.1
Nucleotide Accession #:
NM_001165412.1
Protein Size (# AA):
968
Molecular Weight:
105 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express NFKB1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express NFKB1.

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