NFKB1 Antibody - middle region (AVARP09048_P050)

Catalog No: AVARP09048_P050

WB Suggested Anti-NFKB1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: THP-1 cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NFKB1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 92%; Dog: 85%; Horse: 85%; Human: 100%; Mouse: 85%; Pig: 92%; Rabbit: 85%; Rat: 78%
• Peptide Sequence: Synthetic peptide located within the following region: LRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGK
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-NFKB1 (AVARP09048_P050) antibody is Catalog # AAP30581 (Previous Catalog # AAPP01233)
• Reference: Droll,L., (2008) Biochem. Biophys. Res. Commun. 371 (4), 626-629

Target Info

• Gene Symbol: NFKB1
• Gene Full Name: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
• Alias Symbols: KBF1, EBP-1, NF-kB, CVID12, NF-kB1, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B1, NF-kappabeta
• NCBI Gene Id: 4790
• Protein Name: Nuclear factor NF-kappa-B p105 subunit
• Description of Target: NFKB1 is a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B.This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P19838-2
• Protein Accession #: NP_003989
• Nucleotide Accession #: NM_003998
• Protein Size (# AA): 969
• Molecular Weight: 105kDa
• Protein Interactions: FBXW11; UBC; RELB; RELA; REL; NFKB2; HDAC1; BCL3; NFKB1; RPS3; HIF1AN; NFKBIA; MPP6; PELP1; PLD3; MXD3; IKBKG; RL2; TP63; SRF; MAP3K8; PML; SERPINA3; SPPL2A; TNIP2; NFKBIZ; COPS5; YWHAQ; RGS14; NR4A1; GLUL; ABCC2; TNIP1; COPB2; YY1; PARP1; RPS6KA5; BTRC;