Catalog No: OACA03360
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OACA03360
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Datasheets/ManualsPrintable datasheet for NFE2L1 Antibody (OACA03360) (OACA03360)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Human Endoplasmic reticulum membrane sensor NFE2L1 protein (251-550AA)
PurificationProtein G Purified
ConcentrationVaries by lot. See vial for concentration.
Purity>95%
Application InfoIHC: 1:20~200
IF: 1:50~200
Gene SymbolNFE2L1
Gene Full Namenuclear factor, erythroid 2 like 1
Alias Symbolsendoplasmic reticulum membrane sensor NFE2L1;LCR-F1;locus control region-factor 1;NFE2-related factor 1;NF-E2-related factor 1;NRF1;nuclear factor erythroid 2-related factor 1;nuclear factor, erythroid derived 2, like 1;protein NRF1, p120 form;TCF11;TCF-11;Transcription factor 11;transcription factor 11 (basic leucine zipper type);transcription factor HBZ17;transcription factor LCR-F1.
NCBI Gene Id4779
Protein NameEndoplasmic reticulum membrane sensor NFE2L1
Description of TargetEndoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482).
Uniprot IDQ14494
Protein Accession #NP_001317191
Nucleotide Accession #NM_001330262
  1. What is the species homology for "NFE2L1 Antibody (OACA03360)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "NFE2L1 Antibody (OACA03360)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "NFE2L1 Antibody (OACA03360)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "NFE2L1 Antibody (OACA03360)"?

    This target may also be called "endoplasmic reticulum membrane sensor NFE2L1;LCR-F1;locus control region-factor 1;NFE2-related factor 1;NF-E2-related factor 1;NRF1;nuclear factor erythroid 2-related factor 1;nuclear factor, erythroid derived 2, like 1;protein NRF1, p120 form;TCF11;TCF-11;Transcription factor 11;transcription factor 11 (basic leucine zipper type);transcription factor HBZ17;transcription factor LCR-F1." in publications.

  5. What is the shipping cost for "NFE2L1 Antibody (OACA03360)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "NFE2L1 Antibody (OACA03360)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "NFE2L1 Antibody (OACA03360)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "NFE2L1 Antibody (OACA03360)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "NFE2L1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "NFE2L1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "NFE2L1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "NFE2L1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "NFE2L1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "NFE2L1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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