NFATC4 Antibody (Phospho-Ser168/170) (OASG04971)

Catalog No: OASG04971

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
  Cellular Localization: Cytoplasm Nucleus Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
  Tissue Specificity: Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human NFATc4 around the phosphorylation site of S168/S170. Location: 110-190aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Ser168/170
• Specificity: Phospho-NFATc4 (S168/S170) Polyclonal Antibody detects endogenous levels of NFATc4 protein only when phosphorylated at S168/S170.
• Application Info: WB 1:500~2000
  IHC 1:100~300
  ELISA 1:5000
  

Target Info

• Gene Symbol: NFATC4
• Gene Full Name: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
• Alias Symbols: NFAT3, NF-AT3, NF-ATC4
• NCBI Gene Id: 4776; 73181;
• Description of Target: This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants.
• Uniprot ID: Q14934, Q8K120
• Molecular Weight: 140 kDa