NFATC1 Antibody - N-terminal region : FITC (P100981_P050-FITC)

Catalog No: P100981_P050-FITC

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Dog, Guinea Pig
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: WB, IHC
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NFATC1
• Predicted Homology Based on Immunogen Sequence: Dog: 91%; Guinea Pig: 84%; Human: 100%; Mouse: 91%
• Peptide Sequence: Synthetic peptide located within the following region: MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-NFATC1 (P100981_P050-FITC) antibody is Catalog # AAP31109 (Previous Catalog # AAPP01848)
• Reference: Crotti,T.N., (2008) J. Cell. Physiol. 215 (3), 636-644

Target Info

• Gene Symbol: NFATC1
• Gene Full Name: Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
• Alias Symbols: NFAT2, NFATc, NF-ATC, NF-ATc1.2
• NCBI Gene Id: 4772
• Protein Name: Nuclear factor of activated T-cells, cytoplasmic 1
• Description of Target: NFATC1 is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Different isoforms of this protein may regulate inducible expression of different cytokine genes. The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
• Uniprot ID: O95644-2
• Protein Accession #: NP_765978
• Nucleotide Accession #: NM_172390
• Protein Size (# AA): 716
• Molecular Weight: 78kDa
• Protein Interactions: YWHAQ; OGT; PML; GZF1; FOXP3; HDAC4; PIAS1; SUMO1; UBE2I; RPS6KB1; RPS6KA3; HDAC2; HDAC1; HNRNPA1; TUBA1A; KPNB1; HDAC5; KAT2B; EP300; PARP1; HDAC3; PPP3R1; MAPK14; GNB2L1; PRKCA; SPI1; PIM1; EGR2; EGR1;