NF2 Recombinant Protein (OPCD05643)

Catalog No: OPCD05643

NF2 Recombinant Protein (OPCD05643) using SDS-PAGE

NF2 Recombinant Protein (OPCD05643) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Asp30-Arg311
  Subcellular Location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cytoplasm, cytoskeleton. Nucleu
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Nf2
• Gene Full Name: neurofibromin 2
• Alias Symbols: me;merlin;moesin-ezrin-radixin-like protein;neurofibromatosis 2;Neurofibromin-2;schw;schwannomin.
• NCBI Gene Id: 18016
• Protein Name: Merlin
• Description of Target: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium.
• Uniprot ID: P46662
• Protein Accession #: NP_001239179.1
• Nucleotide Accession #: NM_001252250.1
• Protein Size (# AA): Asp30~Arg311
• Molecular Weight: 37.16kDa