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NF2 Antibody - C-terminal region (ARP63180_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP63180_P050-FITC Conjugated

ARP63180_P050-HRP Conjugated

ARP63180_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
NF2
Official Gene Full Name:
Neurofibromin 2 (merlin)
NCBI Gene Id:
4771
Protein Name:
Merlin
Swissprot Id:
P35240-4
Protein Accession #:
NP_861968
Nucleotide Accession #:
NM_181830
Alias Symbols:
ACN, BANF, SCH
Replacement Item:
This antibody may replace item sc-172383 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
Protein Size (# AA):
507
Molecular Weight:
56kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express NF2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express NF2.
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Complete computational species homology data:
Anti-NF2 (ARP63180_P050)
Peptide Sequence:
Synthetic peptide located within the following region: MAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPA
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
VPRBP; CD44; UBC; KDM1A; AMOTL2; YAP1; PPP1R8; UBD; CCNB1IP1; HGS; CUL4A; DDB1; GPS1; WWC1; PYGO2; AMOT; SCHIP1; SGSM3; NF2; TSC1; TARBP2; SLC9A3R1; PAK1; XPO1; PXN; SDCBP; RALGDS; SPTBN1; ERBB2; ITGB1; EZR; CTNNB1; AGAP2; AKT1; RIT1; ARHGAP32; SOS1; MED2
Blocking Peptide:
For anti-NF2 (ARP63180_P050) antibody is Catalog # AAP63180
Datasheets/Manuals:
Printable datasheet for anti-NF2 (ARP63180_P050) antibody
Publications:

Vasilyeva, NA; Murzina, GB; Kireev, II; Pivovarov, AS; Influence of Membrane Receptor Lateral Diffusion on the Short-Term Depression of Acetylcholine-Induced Current in Helix Neurons. , (2017). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 28236056

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