Nelfinavir mesylate (OOMC00056)

Catalog No: OOMC00056

Product Info

• Product Format: Powder
• Additional Information: CAS: 159989-65-8
  Molecular Formula: C32H45N3O4S - CH3SO3H
  Chemical Name: (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
  Primary Activity: Protease inhibitor: HIV-1 protease, Autophagy modulator
  COVID-19 Rationale: Inhibits SARS-CoV-2 in cells
• Reconstitution and Storage: Soluble in DMSO (up to 70 mg/ml). Store at -20C.
• Purity: > 98%
• Reference: 1) Olmo et al. (2006), A review of nelfinavir for the treatment of HIV infection; Expert Opin. Drug Metab. Toxicol., 2 285 2) Bruning et al. (2010), New prospects for nelfinavir in non-HIV-related diseases; Curr. Mol. Pharmacol., 3 91 3) Gills et al. (2007), Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo; Clin. Cancer Res, 13 5183 4) Shim et al. (2012), Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir; J. Natl. Cancer Inst,, 104 1576

Target Info

• Alias Symbols: AG-1343
• Molecular Weight: 663.9 g/mol