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- $55: Antibody & Protein in US
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| Datasheets/Manuals | Printable datasheet for OAAB16859 |
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| Predicted Species Reactivity | Human |
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| Product Format | Liquid PBS with 0.09% (W/V) sodium azide. |
| Clonality | Polyclonal |
| Isotype | Ig |
| Host | Rabbit |
| Application | WB |
| Additional Information | Function: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. Cellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells. Tissue Location: Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma. |
| Reconstitution and Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | This NEK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 573-604 amino acids from the C-terminal region of human NEK8. |
| Purification | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Concentration | 2 mg/ml |
| Application Info | WB: 1:1000 |
| Gene Symbol | NEK8 |
|---|---|
| Alias Symbols | JCK, NPHP9, RHPD2, NEK12A |
| NCBI Gene Id | 284086 |
| Protein Name | Serine/threonine-protein kinase Nek8 |
| Description of Target | NEK8 is a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. |
| Uniprot ID | Q86SG6 |
| Protein Accession # | NP_835464.1 |
| Molecular Weight | 75 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "NEK8 Antibody - C-terminal region (OAAB16859)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "NEK8 Antibody - C-terminal region (OAAB16859)"?
This item is available "Domestic: within 1 week delivery | International: 1 week".
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What buffer format is "NEK8 Antibody - C-terminal region (OAAB16859)" provided in?
This item is provided in "Liquid PBS with 0.09% (W/V) sodium azide. ".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "NEK8 Antibody - C-terminal region (OAAB16859)"?
This target may also be called "JCK, NPHP9, RHPD2, NEK12A" in publications.
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What is the shipping cost for "NEK8 Antibody - C-terminal region (OAAB16859)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "NEK8 Antibody - C-terminal region (OAAB16859)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "NEK8 Antibody - C-terminal region (OAAB16859)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "75 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "NEK8 Antibody - C-terminal region (OAAB16859)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "NEK8"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "NEK8"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "NEK8"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "NEK8"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "NEK8"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "NEK8"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
