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Catalog No: OOMC00061
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OOMC00061
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N4-Hydroxycytidine (OOMC00061)

Datasheets/ManualsPrintable datasheet for OOMC00061
Product Info
Product FormatPowder
Additional InformationCAS: 3258-02-4
Molecular Formula: C9H13N3O6
::Chemical Name: 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
::Primary Activity: Antiviral (novel)
::COVID-19 Rationale: Has antiviral activity against SARS-CoV-2
Reconstitution and StorageSoluble in DMSO (up to 25 mg/ml) or in Water (up to 15 mg/ml with warming). Store at -20C.
Purity> 98%
Reference1) Janion and Glickman (1980), N4-hydroxycytidine: a mutagen specific for AT to GC transitions; Mutat. Res., 72 43 2) Stuyver et al. (2003), Ribonucleotide analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture; Antimicrob. Agents Chemother., 47 244 3) Costantini et al. (2012), Antiviral activity of nucleoside analogues against norovirus; Antivir. Ther., 17 981 4) Reynard et al. (2015), Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication; Viruses, 7 6233 5) Ehteshami et al. (2017), Characterization of -D-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus; Antimicrob. Agents Chemother., 61 e02395-16 6) Yoon et al. (2018), Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses; Antimicrob. Agents Chemother., 62 e00766-18 7) Barnard et al. (2004), Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine; Antivir. Chem. Chemother., 15 15 8) Pyrc et al. (2006), Inhibition of human coronavirus NL63 infection at early stages of the replication cycle; Antimicrob. Agents Chemother., 50 2000 9) Toots et al. (2019), Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia; Sci. Transl. Med., 11 eaax5866
Alias Symbolsbeta-D-N4-hydroxycytidine, EIDD-1931
Molecular Weight259.22 g/mol
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