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Catalog No: OASL01207
Size:50ul
Price: $269.00
SKU
OASL01207
Availability: Domestic: within 2 week delivery | International: 2 weeks
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OASL01207
Product Info
Product FormatLiquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
ClonalityMonoclonal
IsotypeIgG1, Kappa
HostMouse
ApplicationIHC-P
Additional InformationBackground: myelin basic protein(MBP) Homo sapiens the protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. 
::Function: alternative products: additional isoforms seem to exist, developmental stage: expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Expression of isoform MBP2 is more evident at 16 weeks and its relative proportion declines thereafter, disease: the reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease), the classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination.
::Location: cytoplasmic
::Expression: Amygdala, Brain, Corpus callosum, Embryonic spinal cord, Epithelium, Hippocampus, Lung, Sk.
Reconstitution and StorageStore at -20C for one year. Avoid repeated freeze/thaw cycles.
ImmunogenSynthesized peptide derived from human Myelin Basic Protein(MBP)
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration1 mg/ml
SpecificityThis antibody detects endogenous levels of human Myelin Basic Protein(MBP)
Application InfoIHC-P 1:200
Gene SymbolMBP
Alias SymbolsMBP
NCBI Gene Id4155
Protein NameMyelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein)
Uniprot IDP02686
  1. What is the species homology for "Myelin Basic Protein Antibody (OASL01207)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "".

  2. How long will it take to receive "Myelin Basic Protein Antibody (OASL01207)"?

    This item is available "Domestic: within 2 week delivery | International: 2 weeks".

  3. What buffer format is "Myelin Basic Protein Antibody (OASL01207)" provided in?

    This item is provided in "Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Myelin Basic Protein Antibody (OASL01207)"?

    This target may also be called "MBP" in publications.

  5. What is the shipping cost for "Myelin Basic Protein Antibody (OASL01207)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Myelin Basic Protein Antibody (OASL01207)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Myelin Basic Protein Antibody (OASL01207)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Myelin Basic Protein Antibody (OASL01207)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "MBP"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MBP"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MBP"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MBP"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MBP"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MBP"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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