Mycophenolic acid (OOMC00029)

Catalog No: OOMC00029

Product Info

• Product Format: Powder
• Additional Information: CAS: 24280-93-1
  Molecular Formula: C17H20O6
  Chemical Name: 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexanoic acid
  Primary Activity: Immunosuppressant
  COVID-19 Rationale: Inhibits IMPDH2, which interacts with SARS-CoV-2 Nsp14; Inhibits SARS-CoV-2 in cells
• Reconstitution and Storage: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 30 mg/ml). Store at room temperature.
• Purity: > 98%
• Reference: 1) Eugui et al. (1991), Lymphocyte-selective cyostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion; Scand. J. Immunol., 33 161 2) Jonsson et al. (2002), Mycophenolic acid inhibits inosine 5’-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide and LDH in macrophages; Cell. Immunol., 216 93 3) Allison et al. (1993), Mechanisms of action of mycophenolic acid; Ann. NY Acad. Sci., 696 63 4) Quemeneur et al. (2002), Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis; J. Immunol., 169 2747

Target Info

• Alias Symbols: NSC129185
• Molecular Weight: 320.35 g/mol