MX1 Recombinant Protein (OPCD05478)

Catalog No: OPCD05478

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser80-Leu342
  Subcellular Location: Cytoplasm
  Predicted Isoelectric Point: 5.8
  Phenomenon explanation:
  The possible reasons that the actual band size differs from the predicted are as follows:
  1.Splice variants: Alternative splicing may create different sized proteins from the same gene.
  2. Relative charge: The composition of amino acids may affects the charge of the protein.
  3. Post-translational modification: Phosphorylation, glycosylation, methylation etc.
  4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleavedto give the active form.
  5. Polymerization of the target protein: Dimerization, multimerization etc.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: MX1
• Gene Full Name: MX dynamin like GTPase 1
• Alias Symbols: IFI78;IFI-78K;interferon-induced GTP-binding protein Mx1;interferon-induced protein p78;interferon-inducible protein p78;interferon-regulated resistance GTP-binding protein MxA;lncMX1-215;MX;MxA;myxoma resistance protein 1;myxovirus (influenza virus) resistance 1, interferon-inducible protein p78;Myxovirus resistance protein 1.
• NCBI Gene Id: 4599
• Protein Name: Interferon-induced GTP-binding protein Mx1
• Description of Target: Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
• Uniprot ID: P20591
• Protein Accession #: NP_001138397.1
• Nucleotide Accession #: NM_001144925.2
• Protein Size (# AA): Ser80~Leu342
• Molecular Weight: 34kDa