MVP Antibody - N-terminal region (ARP58642_P050)

Catalog No: ARP58642_P050

WB Suggested Anti-MVP Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: COLO205 cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MVP
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
• Peptide Sequence: Synthetic peptide located within the following region: MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRM
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-MVP (ARP58642_P050) antibody is Catalog # AAP58642 (Previous Catalog # AAPP35779)
• Reference: de (2008) Cytometry B Clin Cytom 74 (3), 163-168

Target Info

• Gene Symbol: MVP
• Gene Full Name: Major vault protein
• Alias Symbols: LRP, VAULT1
• NCBI Gene Id: 9961
• Protein Name: Major vault protein
• Description of Target: MVP is required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
• Uniprot ID: Q14764
• Protein Accession #: NP_005106
• Nucleotide Accession #: NM_005115
• Protein Size (# AA): 893
• Molecular Weight: 98kDa
• Protein Interactions: MVP; SKIL; TRIM27; REL; PLSCR1; MEOX2; MEOX1; MDFI; KPNA3; GOLGA2; DLX2; CAMK2B; AES; TRIP6; TRAF2; TP53; TFCP2; TCF4; SUMO2; NOTCH2NL; CCDC36; TRIM42; FAM154A; PIH1D2; RAB3IP; RIMBP3; C1orf94; RHOXF2; ZMIZ2; OBFC1; RFWD2; MKL1; VAC14; BANP; FAM46C; KCTD9