MUSK Antibody - C-terminal region (OAAB17178)

Catalog No: OAAB17178

Size:400ul

MUSK Antibody (C-term) (Cat. # OAAB17178) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: FC
• Additional Information: Precautions: MUSK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity)
  Cellular Location: Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (Probable) Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction (Probable)
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This MUSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-859 amino acids from the C-terminal region of human MUSK.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: FC: 1:10~50
  WB: 1:1000
  IHC-P: 1:50~100

Target Info

• Gene Symbol: MUSK
• Alias Symbols: CMS9, FADS, FADS1
• NCBI Gene Id: 4593
• Protein Name: Muscle, skeletal receptor tyrosine-protein kinase
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: O15146
• Protein Accession #: NP_001159752.1
• Molecular Weight: 97056 Da