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Catalog No: OAAB17178
Size:400ul
Price: $438.00
SKU
OAAB17178
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAB17178
Product Info
Predicted Species ReactivityHuman
Product FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationFC
Additional InformationPrecautions: MUSK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
::Function: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity)
::Cellular Location: Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (Probable) Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction (Probable)
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis MUSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-859 amino acids from the C-terminal region of human MUSK.
Predicted Homology Based on Immunogen SequenceHuman
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Application InfoFC: 1:10~50
WB: 1:1000
IHC-P: 1:50~100
Gene SymbolMUSK
Alias SymbolsCMS9, FADS, FADS1
NCBI Gene Id4593
Protein NameMuscle, skeletal receptor tyrosine-protein kinase
Description of TargetPurified Rabbit Polyclonal Antibody (Pab)
Uniprot IDO15146
Protein Accession #NP_001159752.1
Molecular Weight97056 Da
  1. What is the species homology for "MUSK Antibody - C-terminal region (OAAB17178)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "MUSK Antibody - C-terminal region (OAAB17178)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "MUSK Antibody - C-terminal region (OAAB17178)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "MUSK Antibody - C-terminal region (OAAB17178)"?

    This target may also be called "CMS9, FADS, FADS1" in publications.

  5. What is the shipping cost for "MUSK Antibody - C-terminal region (OAAB17178)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "MUSK Antibody - C-terminal region (OAAB17178)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "MUSK Antibody - C-terminal region (OAAB17178)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "97056 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "MUSK Antibody - C-terminal region (OAAB17178)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "MUSK"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MUSK"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MUSK"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MUSK"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MUSK"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MUSK"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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