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- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
| Datasheets/Manuals | Printable datasheet for MTRR Antibody (OACA06439) (OACA06439) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Human Methionine synthase reductase protein (1-725AA) |
| Purification | Protein G Purified |
| Preservative | 0.03% Proclin 300 |
| Formulation | 50% Glycerol, 0.01M PBS, PH 7.4 |
| Reference | [1]"Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry."Wolthers K.R., Lou X., Toogood H.S., Leys D., Scrutton N.S.Biochemistry 46:11833-11844(2007). [2]"Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism."Wilson A., Leclerc D., Rosenblatt D.S., Gravel R.A.Hum. Mol. Genet. 8:2009-2016(1999). [3]"Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida."Doolin M.-T., Barbaux S., McDonnell M., Hoess K., Whitehead A.S., Mitchell L.E.Am. J. Hum. Genet. 71:1222-1226(2002). |
| Gene Symbol | MTRR |
|---|---|
| Gene Full Name | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase |
| Alias Symbols | [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing);aqCbl reductase;aquacobalamin reductase;cblE;methionine synthase reductase;methionine synthase reductase, mitochondrial;MSR. |
| NCBI Gene Id | 4552 |
| Protein Name | Methionine synthase reductase |
| Description of Target | Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects. |
| Uniprot ID | Q9UBK8 |
| Protein Accession # | NP_002445 |
| Nucleotide Accession # | NM_002454 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "MTRR Antibody (OACA06439)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "MTRR Antibody (OACA06439)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "MTRR Antibody (OACA06439)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "MTRR Antibody (OACA06439)"?
This target may also be called "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing);aqCbl reductase;aquacobalamin reductase;cblE;methionine synthase reductase;methionine synthase reductase, mitochondrial;MSR." in publications.
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What is the shipping cost for "MTRR Antibody (OACA06439)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "MTRR Antibody (OACA06439)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "MTRR Antibody (OACA06439)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "MTRR Antibody (OACA06439)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "MTRR"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "MTRR"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "MTRR"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "MTRR"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "MTRR"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "MTRR"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
