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MTNR1B Antibody - N-terminal region (ARP64072_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP64072_P050-FITC Conjugated

ARP64072_P050-HRP Conjugated

ARP64072_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Human, Pig, Rabbit
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
MTNR1B
Official Gene Full Name:
Melatonin receptor 1B
NCBI Gene Id:
4544
Protein Name:
Melatonin receptor type 1B
Swissprot Id:
P49286
Protein Accession #:
NP_005950
Nucleotide Accession #:
NM_005959
Alias Symbols:
FGQTL2, MEL-1B-R, MT2
Replacement Item:
This antibody may replace item sc-13174 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.
Protein Size (# AA):
362
Molecular Weight:
40kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MTNR1B.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MTNR1B.
Predicted Homology Based on Immunogen Sequence:
Human: 100%; Pig: 79%; Rabbit: 79%
Complete computational species homology data:
Anti-MTNR1B (ARP64072_P050)
Peptide Sequence:
Synthetic peptide located within the following region: SFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDV
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
GNAI1; GPR50; ITM2C; HNRNPA0; GNB4; PPM1G; PI4KA; PDIA6; VPS35; IRS4; COPA; CTNND1; MTNR1B; MTNR1A; FLNA; YWHAQ; GNB1; GNAI3; GNAI2; HSPA5; CANX;
Blocking Peptide:
For anti-MTNR1B (ARP64072_P050) antibody is Catalog # AAP64072
Datasheets/Manuals:
Printable datasheet for anti-MTNR1B (ARP64072_P050) antibody
Publications:

Santoro, R. et al. Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation. Carcinogenesis 34, 1051-61 (2013). WB, Human, Pig, Rabbit 23354312

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