MTA2 Antibody - C-terminal region : HRP (ARP74648_P050-HRP)

Catalog No: ARP74648_P050-HRP

Size:100ul

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: HRP: Horseradish Peroxidase
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MTA2
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: KDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMAGAGVP
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-MTA2 (ARP74648_P050-HRP) antibody is Catalog # AAP74648
• Reference: N/A

Target Info

• Gene Symbol: MTA2
• Alias Symbols: PID, MTA1L1
• NCBI Gene Id: 9219
• Description of Target: This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
• Uniprot ID: O94776
• Protein Accession #: NP_004730
• Protein Size (# AA): 668
• Molecular Weight: 73kDa
• Protein Interactions: vpr; SUMO2; SUMO3; DNMT3B; DNMT1; NACC2; ZBTB16; UBC; RARA; ZBTB1; RNF2; GPHN; HNRNPR; TRIM28; PPP4R1; ROCK2; SPAG9; POLR2C; POLR2A; MAP4; RPP25; LSM8; GET4; LARP7; CD2AP; NR3C1; MTOR; EHBP1L1; RABEP2; BRCC3; SMEK1; ZGPAT; HDAC1; HDAC2; CSNK1E; MTA3; UBE3