MST1R Recombinant Protein (OPCD05413)

Catalog No: OPCD05413

MST1R Recombinant Protein (OPCD05413) using SDS-PAGE

MST1R Recombinant Protein (OPCD05413) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ile89-Ser275
  Subcellular Location: Membrane; Single-pass type I membrane prote
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Mst1r
• Gene Full Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
• Alias Symbols: CD136;CDw136;friend virus susceptibility 2;Fv;Fv-;Fv2;Fv-2;macrophage-stimulating protein receptor;MSP receptor;p185-Ron;PTK;PTK8;receptor protein tyrosine kinase, c-met-related;Ron;ST;stem cell-derived tyrosine kinase;STK.
• NCBI Gene Id: 19882
• Protein Name: Macrophage-stimulating protein receptor
• Description of Target: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
• Uniprot ID: Q62190
• Protein Accession #: NP_033100.2
• Nucleotide Accession #: NM_009074.2
• Protein Size (# AA): Ile89~Ser275
• Molecular Weight: 25kDa