MST1R Antibody (Phospho-Tyr1238) (OABF01575)

Catalog No: OABF01575

Size:100UL

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti phospho-Ron/MST1R (Tyr1238) Polyclonal Antibody, Unconjugated (OABF01575) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti phospho-Ron/MST1R (Tyr1238) Polyclonal Antibody, Unconjugated (OABF01575) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Predicted Species Reactivity: Human|Monkey|Mouse|Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Western blot
• Additional Information: Subcellular location: Cytoplasm
  Modification: Phosphorylation (Tyr1238)
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human MST1R around the phosphorylation site of Tyr1238
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: MST1R
• Gene Full Name: macrophage stimulating 1 receptor
• Alias Symbols: CD136;CDw136;c-met-related tyrosine kinase;macrophage-stimulating protein receptor;MSP receptor;NPCA3;p185-Ron;Protein-tyrosine kinase 8;PTK8;PTK8 protein tyrosine kinase 8;RON;S13 avian erythroblastosis oncogene homolog;S13 erythroblastosis oncogene homolog;SEA.
• NCBI Gene Id: 4486
• Protein Name: Macrophage-stimulating protein receptor
• Description of Target: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
• Uniprot ID: Q04912