MSH6 Antibody - middle region (OASG03256)

Catalog No: OASG03256

Size:100 uL

Western Blot using A549

Western Blot using COS7

Product Info

• Predicted Species Reactivity: Human, Mouse, Monkey
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC, IF
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the Internal region of human GTBP. Location: 310-390aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: GTBP Polyclonal Antibody detects endogenous levels of GTBP protein.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;

Target Info

• Gene Symbol: MSH6
• Gene Full Name: mutS homolog 6
• Alias Symbols: GTBP, HSAP, p160, GTMBP, HNPCC5, MMRCS3
• NCBI Gene Id: 2956; 17688;
• Description of Target: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
• Uniprot ID: P52701, P54276
• Molecular Weight: 170 kDa