Mouse Prkaca/Prkacb Antibody - C-terminal region (OAAB10759)

Catalog No: OAAB10759

Size:400ul

Mouse Prkaca/Prkacb Antibody (C-term) (Cat. #OAAB10759) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the Prkaca/Prkacb antibody detected the Prkaca/Prkacb protein (arrow).

Mouse Prkaca/Prkacb Antibody (C-term) (Cat. #OAAB10759) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Prkaca/Prkacb antibody detected the Prkaca/Prkacb protein (arrow).

Mouse Prkaca/Prkacb Antibody (C-term) (OAAB10759)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Prkaca/Prkacb Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Pig
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC
• Additional Information: Precautions: Mouse Prkaca/Prkacb Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity)
  Cellular Location: Cytoplasm (By similarity). Cell membrane (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity)
  Tissue Location: Isoform 1 is found in all tissues examined, with the highest expression in the brain and very low levels in the testis. Isoform 2 is strongly expressed in the brain, in the prelimbic and insular cortex. Isoform 3 is also found only in the brain, but at very low levels
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This Mouse Prkaca/Prkacb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-319 amino acids from the C-terminal region of mouse Prkaca/Prkacb.
• Predicted Homology Based on Immunogen Sequence: Cow; Human; Mouse; Pig; Rat
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000
  IHC-P: 1:10~50

Target Info

• Gene Symbol: Prkacb
• Alias Symbols: Pka, CbPKA, Pkacb
• NCBI Gene Id: 18749
• Protein Name: cAMP-dependent protein kinase catalytic subunit beta
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: P68181
• Protein Accession #: NP_001157670.1
• Molecular Weight: 40708 Da