p21Cip1 Antibody (Phospho-Ser125) (OAAB16424)

Catalog No: OAAB16424

Size:400ul

Dot blot analysis of Mouse p21Cip1 Antibody (Phospho S125) Phospho-specific Pab (Cat. # OAAB16424) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: DB
• Additional Information: Precautions: Mouse p21Cip1 Antibody (Phospho S125) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity)
  Cellular Location: Cytoplasm (By similarity). Nucleus.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This mouse p21Cip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S125 of mouse p21Cip1.
• Predicted Homology Based on Immunogen Sequence: Mouse
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: DB: 1:500

Target Info

• Gene Symbol: Cdkn1a
• Alias Symbols: CI, P2, SD, CAP, CDK, P21, Waf, mda, CDKI, CIP1, Cdkn, SDI1, Waf1, mda6, p21C, p21W, CAP20, Cdkn1, p21WAF, p21Cip1
• NCBI Gene Id: 12575
• Protein Name: Cyclin-dependent kinase inhibitor 1
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: P39689
• Protein Accession #: NP_001104569.1
• Molecular Weight: 17785 Da