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- $55: Antibody & Protein in US
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Datasheets/Manuals | Printable datasheet for OAAB10454 |
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Predicted Species Reactivity | Human, Mouse, Rat |
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Product Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Clonality | Polyclonal |
Isotype | Ig |
Host | Rabbit |
Application | WB, IHC |
Additional Information | Precautions: Mouse Map2k7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
:: | Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis |
:: | Cellular Location: Nucleus. Cytoplasm. Tissue Location: Expressed at high levels in brain, lung, liver, skeletal muscle, kidney, and testis and at lower levels in the heart and spleen |
Reconstitution and Storage | Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | This Mouse Map2k7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-233 amino acids from the Central region of mouse Map2k7. |
Predicted Homology Based on Immunogen Sequence | Human; Mouse; Rat |
Concentration | Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Application Info | WB: 1:1000 IHC-P: 1:10~50 |
Gene Symbol | Map2k7 |
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Alias Symbols | sek, Jnkk, Mek7, Mkk7, Prkm, sek2, Jnkk2, MEK 7, JNKK 2, Mapkk7, Prkmk7, MAPKK 7, 5930412N11Rik |
NCBI Gene Id | 26400 |
Protein Name | Dual specificity mitogen-activated protein kinase kinase 7 |
Description of Target | Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Uniprot ID | Q8CE90 |
Protein Accession # | NP_001036022.1 |
Molecular Weight | 59312 Da |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "Mouse Map2k7 Antibody - middle region (OAAB10454)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".
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How long will it take to receive "Mouse Map2k7 Antibody - middle region (OAAB10454)"?
This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".
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What buffer format is "Mouse Map2k7 Antibody - middle region (OAAB10454)" provided in?
This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "Mouse Map2k7 Antibody - middle region (OAAB10454)"?
This target may also be called "sek, Jnkk, Mek7, Mkk7, Prkm, sek2, Jnkk2, MEK 7, JNKK 2, Mapkk7, Prkmk7, MAPKK 7, 5930412N11Rik" in publications.
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What is the shipping cost for "Mouse Map2k7 Antibody - middle region (OAAB10454)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "Mouse Map2k7 Antibody - middle region (OAAB10454)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "Mouse Map2k7 Antibody - middle region (OAAB10454)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "59312 Da".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "Mouse Map2k7 Antibody - middle region (OAAB10454)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "MAP2K7"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "MAP2K7"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "MAP2K7"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "MAP2K7"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "MAP2K7"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "MAP2K7"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.