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Catalog No: OASB01722 (Formerly GWB-999BEE)
Size:500UG
Price: $439.00
SKU
OASB01722
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for Mouse CD152/CTLA-4 Antibody : FITC (OASB01722)
Product Info
Tested Species ReactivityMouse
Predicted Species ReactivityMouse
ClonalityMonoclonal
Clone1B8
IsotypeIgG
HostHamster
ConjugationFITC
ApplicationFC
Additional InformationDescription: The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the costimulatory molecule CD28 and both molecules share common B7 family counter-receptors. However CD152 is thought to be a negative regulator of T cell activation and may play a role in apoptotic control of T cells. CD152 is relatively conserved among humans, mice, and chickens.
Reconstitution and StorageStore at 2-8C
ImmunogenExtracellular portion of murine CTLA-4 fused to a murine IgG2a
Concentration0.5 mg/mL
SpecificityCD152
CharacterizationTo insure acceptable performance, each batch of product is tested to conform to the characteristics of astandard reference reagent by flow cytometry.
WarningReagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin,eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash withcopious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yieldstoxic hydrazoic acid under acidic conditions. Dilute azide- containing compounds in running water beforediscarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
DilutionFlow Cytometry: Fluorescein conjugate
Biotin conjugate
R-phycoerythrin conjugate
<= 3 ug/106 cells
<= 3 ug/106 cells
<= 0.3 ug/106 cells
Application InfoFlow cytometry 5, In vitro functional studies 5
Other Applications DataSince applications vary, you should determine the optimum workingdilution of the product that is appropriate for your specific need.
Other Applications Image 1 Data Amount Used: ≤ 3 Ug/106 cells CHO cells transfected with CD152/CTLA-4 were stained with either hamster IgG-FITC or hamster anti-mouse CD152-FITC, following which large cells were gated and analyzed by flow cytometry.
Reference1. Walunas, T. L., et al. 1994. Immunity 1:405
2. Perkins, D., et al. 1996. J. Immunol. 156:4154
3. Leach, D. R., M.K. Krummel and J.P. Allison. 1996. Science 271:1734
4. Freeman, G. J., et al. 1992. J. Immunol. 149:3795
5. Ben- David, H., M. Sela, and E. Mozes. 2005. Proc. Natl. Sci. USA 102(6):2028.
Storage- The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mMborate buffered saline, pH 8.2. No preservatives or amine- containing buffer salts added. Store at 2- 8 C
- The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2- 8 C
- The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2- 8 C
- The R- phycoerythrin (R- PE) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizingagent. Store at 2- 8 C. Do not freeze!
- The low endotoxin, azide- free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mLof PBS. Aliquot and store at or below - 20 C
- Protect conjugated forms from light. Aliquot and freeze the low endotoxin, azide- free product at - 20 Cimmediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored asdirected.
Gene SymbolCTLA4
Gene Full NameCytotoxic T-lymphocyte protein 4
Alias SymbolsCtla, Ly-5, Cd152, Ly-56, Ctla-4
NCBI Gene Id12477
Protein Namecytotoxic T-lymphocyte protein 4
Description of TargetThis gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Uniprot IDP09793
Protein Accession #NP_033973.2
Nucleotide Accession #NM_009843.4
  1. What is the species homology for "Mouse CD152/CTLA-4 Antibody : FITC (OASB01722)"?

    The tested species reactivity for this item is "Mouse". This antibody is predicted to have homology to "Mouse".

  2. How long will it take to receive "Mouse CD152/CTLA-4 Antibody : FITC (OASB01722)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "Mouse CD152/CTLA-4 Antibody : FITC (OASB01722)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Mouse CD152/CTLA-4 Antibody : FITC (OASB01722)"?

    This target may also be called "Ctla, Ly-5, Cd152, Ly-56, Ctla-4" in publications.

  5. What is the shipping cost for "Mouse CD152/CTLA-4 Antibody : FITC (OASB01722)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Mouse CD152/CTLA-4 Antibody : FITC (OASB01722)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Mouse CD152/CTLA-4 Antibody : FITC (OASB01722)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Mouse CD152/CTLA-4 Antibody : FITC (OASB01722)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CTLA4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CTLA4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CTLA4"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CTLA4"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CTLA4"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CTLA4"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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