Mouse Brsk2 Antibody - middle region (OAAB11466)

Catalog No: OAAB11466

Size:400ul

Mouse Brsk2 Antibody (Center) (Cat. #OAAB11466) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the Brsk2 antibody detected the Brsk2 protein (arrow).

Product Info

• Predicted Species Reactivity: Mouse, Rat
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
• Additional Information: Precautions: Mouse Brsk2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress
  Cellular Location: Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm, perinuclear region (By similarity) Endoplasmic reticulum (By similarity). Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin (By similarity)
  Tissue Location: Detected in pancreas islets and in brain (at protein level). Detected in brain and pancreas
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This Mouse Brsk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-356 amino acids from the Central region of mouse Brsk2.
• Predicted Homology Based on Immunogen Sequence: Mouse; Rat
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: Brsk2
• Alias Symbols: SA, SADA, SAD-A, 4833424K13Rik
• NCBI Gene Id: 75770
• Protein Name: Serine/threonine-protein kinase BRSK2
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q69Z98
• Protein Accession #: NP_001009929.1
• Molecular Weight: 81733 Da