- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for Human TRAIL Antibody : Biotin (OASB01317) |
---|
Tested Species Reactivity | Human |
---|---|
Predicted Species Reactivity | Human |
Clonality | Monoclonal |
Clone | SB91a |
Isotype | IgG2b |
Host | Mouse |
Conjugation | Biotin |
Additional Information | Description: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8. Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer. |
Reconstitution and Storage | Store at 2-8C |
Immunogen | Recombinant TRAIL |
Concentration | 0.5 mg/mL |
Specificity | TRAIL |
Characterization | To ensure acceptable performance, each batch of product is tested by ELISA to conform tocharacteristics of a standard reference reagent. |
Dilution | ELISA Purified Antibody 0.1 – 1.0ug/mL Biotin Conjugate 0.1 – 1.0ug/mL |
Application Info | ELISA |
Storage | - The purified (UNLB) antibody is supplied as 0.5mg purified immunoglobulin in 1.0mL of100mM borate buffered saline, pH 8.0; store at 2- 8 C - The biotin (BIOT) conjugate is supplied as 0.5mg purified immunoglobulin in 1.0mL ofPBS/NaN3; store at 2- 8 C - Reagents are stable for the period shown on the label if stored as directed. |
Reference | 1) Aviva Systems Biology, Inc. Unpublished 2) Zamai, L. et al. (1998). J. Exp. Med. 188:2375- 80 3) Jin, Z. and El- Deiry, W.S. (2006). Mol. Cell. Biol. 26:8136- 48 4) Thorburn, A. (2004). Cell. Sign. 16:139- 44 5) Micheau, O. and Tschopp, J. (2003). Cell. 114:181- 90 6) Nagane, M. et al. (2001). Apop. 6:191- 7. |
Gene Symbol | TNFSF10 |
---|---|
Gene Full Name | Tumor necrosis factor ligand superfamily member 10 |
Alias Symbols | TL2, APO2L, CD253, TRAIL, Apo-2L, TNLG6A |
NCBI Gene Id | 8743 |
Protein Name | tumor necrosis factor ligand superfamily member 10 |
Description of Target | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Uniprot ID | P50591 |
Protein Accession # | NP_001177871.1 |
Nucleotide Accession # | NM_001190942.1 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
-
What is the species homology for "Human TRAIL Antibody : Biotin (OASB01317)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".
-
How long will it take to receive "Human TRAIL Antibody : Biotin (OASB01317)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
-
What buffer format is "Human TRAIL Antibody : Biotin (OASB01317)" provided in?
This item is provided in "".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "Human TRAIL Antibody : Biotin (OASB01317)"?
This target may also be called "TL2, APO2L, CD253, TRAIL, Apo-2L, TNLG6A" in publications.
-
What is the shipping cost for "Human TRAIL Antibody : Biotin (OASB01317)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
-
What is the guarantee for "Human TRAIL Antibody : Biotin (OASB01317)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "Human TRAIL Antibody : Biotin (OASB01317)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "Human TRAIL Antibody : Biotin (OASB01317)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "TNFSF10"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "TNFSF10"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "TNFSF10"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "TNFSF10"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "TNFSF10"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "TNFSF10"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.