Human IL-21 Antibody (OASB01354)

Catalog No: OASB01354

Size:500UG

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Borate buffered saline (pH8.2). No preservatives or amine containing buffer salts added.
• Clonality: Monoclonal
• Clone: SB134f
• Isotype: IgG2a
• Host: Mouse
• Conjugation: Unconjugated
• Additional Information: Description: Interleukin-21 (IL-21) is a four helical bundle type I cytokine. The mature form of human IL-21 is a 131 amino acid protein. IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells, and augmentation of antitumor activity of CD8+ T cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
• Reconstitution and Storage: Store at 2-8C
• Immunogen: E. coli-expressed human IL-21
• Concentration: 0.5 mg/mL
• Specificity: IL-21
• Characterization: To ensure acceptable performance, each batch of product is tested by ELISA to conform to characteristics of a standard reference reagent.
• Dilution: ELISA: ≤1 ug/mL
• Reference: 1) Rosanne Spolski and Warren J. Leonard (2008). Annu Rev Immunol 29:57- 79
  2) Ettinger, R., et al. (2005). J. Immunol. 175:7867- 7879
  3) Kuchen, S., et al. (2007). J. Immunol. 179:5886- 5896
  4) Parrish- Novak, J. et al. (2000). Nature. 408:57- 63
  5) Aviva Systems Biology (2009) unpublished observations.

Target Info

• Gene Symbol: IL21
• Gene Full Name: Interleukin-22
• Alias Symbols: Za11, IL-21, CVID11
• NCBI Gene Id: 59067
• Protein Name: interleukin-21
• Description of Target: This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Uniprot ID: Q9HBE4
• Protein Accession #: NP_001193935.1
• Nucleotide Accession #: NM_001207006.2