Catalog No: OASB01336
Size:500UG
Price: $419.00
SKU
OASB01336
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for Human GFAP Antibody : CY3 (OASB01336)
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman
ClonalityMonoclonal
CloneSB61b
IsotypeIgG2b
HostMouse
ConjugationCyanine 3
ApplicationICC, IHC-F, WB
Additional InformationDescription: Glial fibrillary acid protein (GFAP) is a member of the type III intermediate filament family of proteins. GFAP is heavily expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and functions of the cell's cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cell; however, its precise function remains poorly understood. In adults, GFAP levels increase in response to the proliferation of astrocytes associated with Alzheimer's disease, epilepsy, and multiple sclerosis. Antibodies specific for GFAP are useful as markers of astrocytic cells and neural stem cells as well as for distinguishing neoplasms of astrocytic origin from other neoplasms in the central nervous system.
Reconstitution and StorageStore at 2-8C
ImmunogenRecombinant human GFAP
Concentration0.5 mg/mL
SpecificityGFAP
CharacterizationTo ensure acceptable performance, each batch of product is tested by immunohistochemistry and/or Westernblotting to conform to characteristics of a standard reference reagent.
WarningImmunoconjugates contain sodium azide which is very toxic if ingested or inhaled. Avoid contact with skin, eyes,or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copiousamounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoicacid under acidic conditions. Dilute azide- containing compounds in running water before discarding to avoidaccumulation of potentially explosive deposits in lead or copper plumbing.
DilutionImmunohistochemistry: Purified Antibody 5ug/mL
Western Blotting: Purified Antibody 2ug/mL
HRP Conjugate
CY3
1:2,000-1:4,000 w/enhancer 1:5,000-1:10,000
1ug/mL
Application InfoImmunohistochemistry (FS or cultured and methanol-fixed cell lines), Western Blotting
Storage- The purified (UNLB) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of 100 mM boratebuffered saline, pH 8.0; store at 2- 8 C
- HRP conjugate is supplied in 1.0 mL of stock solution in 50% glycerol/50% phosphate buffered saline, pH.7.4
No preservative added. Store at 2- 8 C or long- term at - 20 C
- The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL PBS/NaN3. Store at 2- 8 C
- Reagents are stable for the period shown on the label if stored as directed.
Reference1) Aviva Systems Biology, Inc. Unpublished
2) Lukas, Z. et al. 1989. Expression of vimentin and glial fibrillary acid protein in human developing spinal cord. Histochem. J. 21:693
3) Brenner, M. et al. 2001. Mutations in GFAP, encoding glial fibrillary acid protein, are associated with Alexander's Disease. Nat. Genet
7:118- 120.
Gene SymbolGFAP
Gene Full NameGlial fibrillary acidic protein
Alias SymbolsALXDRD
NCBI Gene Id2670; 14580
Protein Nameglial fibrillary acidic protein
Description of TargetThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Uniprot IDP14136, P03995
Protein Accession #NP_001124491.1
Nucleotide Accession #NM_001131019.2
  1. What is the species homology for "Human GFAP Antibody : CY3 (OASB01336)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "Human GFAP Antibody : CY3 (OASB01336)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "Human GFAP Antibody : CY3 (OASB01336)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Human GFAP Antibody : CY3 (OASB01336)"?

    This target may also be called "ALXDRD" in publications.

  5. What is the shipping cost for "Human GFAP Antibody : CY3 (OASB01336)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Human GFAP Antibody : CY3 (OASB01336)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Human GFAP Antibody : CY3 (OASB01336)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Human GFAP Antibody : CY3 (OASB01336)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "GFAP"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "GFAP"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "GFAP"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "GFAP"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "GFAP"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "GFAP"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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