Human CD95 Antibody : PE (OASB02633)

Catalog No: OASB02633

Size:25T

Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD95-PE.

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Phosphate buffered saline containing 0.1% sodium azide and a stabilizer
• Clonality: Monoclonal
• Host: Mouse
• Conjugation: R-PE
• Application: FC
• Additional Information: Description: CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells indicating that these monoclonal antibodies recognize a functional epitope of CD95.
• Reconstitution and Storage: Store at 2-8C
• Immunogen: Human CD95 transfected L cells
• Concentration: Lot specific
• Specificity: CD95

Target Info

• Gene Symbol: FAS, FAS, FAS, FAS
• Gene Full Name: Fas cell surface death receptor
• Alias Symbols: APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6
• NCBI Gene Id: 355; 574332; 103216224; 105587157
• Protein Name: tumor necrosis factor receptor superfamily member 6
• Description of Target: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
• Uniprot ID: P25445, Q9BDP2, Q9BDN4
• Protein Accession #: NP_000034.1
• Nucleotide Accession #: NM_000043.5