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Catalog No: OASB00962
Size:100UG
Price: $149.00
SKU
OASB00962
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Human CD54/ICAM-1 Antibody (OASB00962)

Datasheets/ManualsPrintable datasheet for Human CD54/ICAM-1 Antibody (OASB00962)
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman
ClonalityMonoclonal
Clone15.2
IsotypeIgG1
HostMouse
ConjugationUnconjugated
ApplicationFC, IHC-F, ICC, IP, WB, BL
Additional InformationDescription: CD54, also known as intercellular cell adhesion molecule-1 (ICAM-1), is a 90 kDa type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It exhibits a wide tissue distribution being expressed on both hematopoietic and non-hematopoietic cells. ICAM-1 expression on leukocytes is low but is rapidly upregulated upon activation. Expression on endothelium and other non-hematopoietic cells is strongly upregulated by inflammatory mediators. The ligands of CD54 are CD11a/LFA-1alpha and CD11b/Mac-1alpha. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels particularly in areas of inflammation. CD54 on antigen-presenting cells (APC) contributes to antigen-specific T cell activation presumably by enhancing interactions between T cells and APC.
Reconstitution and StorageStore at 2-8C
ImmunogenRheumatoid synovial cells and human monocytes
Concentration0.1 mg/mL
SpecificityCD54
CharacterizationTo insure lot to lot consistency, each batch of product is tested by flow cytometry to conform to thecharacteristics of a standard reference reagent.
WarningReagents contain sodium azide which is very toxic if ingested or inhaled. Avoid contact with skin, eyes, orclothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copiousamounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxichydrazoic acid under acidic conditions. Dilute azide- containing compounds in running water beforediscarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
DilutionFlow Cytometry: Purified (UNLB) antibody <= 1 ug/106 cells
Application InfoFlow cytometry, Immunohistochemisty (frozen sections and paraffin sections), Immunoprecipitation, Blocking studies
Other Applications DataSince applications vary, you should determine the optimum workingdilution of the product that is appropriate for your specific need.
Storage- The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 1.0 mL 100 mM boratebuffered saline, pH 8.2. Store at 2- 8 C
- Reagents are stable for the period shown on the label if stored as directed.
Reference1. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte AntigensFacts Book, 2nd Edition, CD54 Section, Academic Press, New York, p. 278
2. Dustin, M.L., and T.A. Springer. 1991. Annu. Rev. Immunol. 9:27
3. Gearing, A.J.H., and W. Newman. 1993. Immunol. Today 14:506
4. Miller, J., R. Knorr, M. Ferrone, R. Houdei, C.P. Carron, and M.L. Dustin. 1995. J. Exp. Med. 182:1231.
Gene SymbolICAM1
Gene Full NameIntercellular adhesion molecule 1
Alias SymbolsBB2, CD54, P3.58
NCBI Gene Id3383; 396750
Protein Nameintercellular adhesion molecule 1
Description of TargetThis gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
Uniprot IDP05362, Q9MZU5
Protein Accession #NP_000192.2
Nucleotide Accession #NM_000201.2
  1. What is the species homology for "Human CD54/ICAM-1 Antibody (OASB00962)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "Human CD54/ICAM-1 Antibody (OASB00962)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "Human CD54/ICAM-1 Antibody (OASB00962)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Human CD54/ICAM-1 Antibody (OASB00962)"?

    This target may also be called "BB2, CD54, P3.58" in publications.

  5. What is the shipping cost for "Human CD54/ICAM-1 Antibody (OASB00962)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Human CD54/ICAM-1 Antibody (OASB00962)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Human CD54/ICAM-1 Antibody (OASB00962)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Human CD54/ICAM-1 Antibody (OASB00962)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ICAM1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ICAM1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ICAM1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ICAM1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ICAM1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ICAM1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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