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Datasheets/Manuals | Printable datasheet for Human CD49f Antibody : FITC (OASB02628) |
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Tested Species Reactivity | Human |
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Predicted Species Reactivity | Human |
Product Format | Liquid. Phosphate buffered saline containing 0.1% sodium azide |
Clonality | Monoclonal |
Host | Mouse |
Conjugation | FITC |
Application | FC, IHC-F, IHC-P |
Additional Information | Description: CD49f is the 125 kDa integrin alpha6 chain which associates noncovalently with the integrin beta1 subunit (CD29) and with the integrin beta4 (CD104) chain to form, respectively, the very late antigen-6 (VLA-6) and alpha6/beta4 integrin heterodimers. VLA-6 is expressed on thymocytes, T lymphocytes, monocytes, and platelets. CD49f/CD29 expression is upregulated on activated T lymphocytes and memory T cells. VLA-6 serves as the laminin receptor on platelets, monocytes, and T cells. VLA-6-mediated binding to laminin provides a costimulatory signal to T cells for activation and proliferation. |
Reconstitution and Storage | Store at 2-8C |
Immunogen | SW1222 human colorectal cell line |
Concentration | Lot specific |
Specificity | CD49f |
Gene Symbol | ITGA6 |
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Gene Full Name | integrin subunit alpha 6 |
Alias Symbols | CD49f, VLA-6, ITGA6B |
NCBI Gene Id | 3655 |
Protein Name | integrin alpha-6 |
Description of Target | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. |
Uniprot ID | P23229 |
Protein Accession # | NP_000201.2 |
Nucleotide Accession # | NM_000210.3 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "Human CD49f Antibody : FITC (OASB02628)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".
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How long will it take to receive "Human CD49f Antibody : FITC (OASB02628)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "Human CD49f Antibody : FITC (OASB02628)" provided in?
This item is provided in "Liquid. Phosphate buffered saline containing 0.1% sodium azide".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "Human CD49f Antibody : FITC (OASB02628)"?
This target may also be called "CD49f, VLA-6, ITGA6B" in publications.
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What is the shipping cost for "Human CD49f Antibody : FITC (OASB02628)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "Human CD49f Antibody : FITC (OASB02628)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "Human CD49f Antibody : FITC (OASB02628)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "Human CD49f Antibody : FITC (OASB02628)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "ITGA6"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "ITGA6"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "ITGA6"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "ITGA6"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "ITGA6"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "ITGA6"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.