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Datasheets/Manuals | Printable datasheet for Fibrillin Antibody : Biotin (OASB02272) |
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Tested Species Reactivity | Human |
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Predicted Species Reactivity | Bovine, Japanese Macaque |
Product Format | Liquid. Phosphate buffered saline containing 0.1% sodium azide |
Clonality | Monoclonal |
Host | Mouse |
Conjugation | Biotin |
Application | EM, ICC, IHC-F, IHC-P, IP, WB |
Additional Information | Description: The fibrillins are extracellular matrix glycoproteins which occur as a major component of a subset of connective tissue microfibrils. These microfibrils have a beaded appearance and a cross-sectional diameter of 10-12 nm. In elastic tissues, these structures are thought to provide the scaffold onto which elastin is assembled to form elastic fibers, although their function in non-elastic tissues is unclear. There is an aberrant expression of fibrillin in Marfan syndrome. The epitope for the monoclonal antibody 11C1.3 has been found to be within exons 18-20 (a.a. 723-909). |
Reconstitution and Storage | Store at 2-8C |
Immunogen | Microfibrils from the zonular apparatus of bovine eye |
Concentration | 0.2 mg/mL |
Specificity | Fibrillin |
Gene Symbol | FBN1, FBN1 |
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Gene Full Name | fibrillin 1 |
Alias Symbols | FBN, SGS, WMS, MASS, MFLS, MFS1, OCTD, SSKS, WMS2, ACMICD, ECTOL1, GPHYSD2 |
NCBI Gene Id | 2200; 281154 |
Protein Name | fibrillin-1 |
Description of Target | This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome. |
Uniprot ID | P35555, P98133 |
Protein Accession # | NP_000129.3 |
Nucleotide Accession # | NM_000138.4 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "Fibrillin Antibody : Biotin (OASB02272)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Bovine, Japanese Macaque".
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How long will it take to receive "Fibrillin Antibody : Biotin (OASB02272)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "Fibrillin Antibody : Biotin (OASB02272)" provided in?
This item is provided in "Liquid. Phosphate buffered saline containing 0.1% sodium azide".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "Fibrillin Antibody : Biotin (OASB02272)"?
This target may also be called "FBN, SGS, WMS, MASS, MFLS, MFS1, OCTD, SSKS, WMS2, ACMICD, ECTOL1, GPHYSD2" in publications.
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What is the shipping cost for "Fibrillin Antibody : Biotin (OASB02272)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "Fibrillin Antibody : Biotin (OASB02272)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "Fibrillin Antibody : Biotin (OASB02272)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "Fibrillin Antibody : Biotin (OASB02272)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "FBN1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "FBN1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "FBN1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "FBN1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "FBN1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "FBN1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.