- Description of Target:
- Morphine is thought to produce reinforcement phenomena via stimulation of κ (kappa), δ (delta), and μ (mu) opioid receptors that regulate stress perception, pain control, reward behavior, and neurohormone secretion in reward-relevant brain systems. It has the highest affinity for ‘, followed by κ (kappa) and δ (delta). Rapid activation of the ?-opioid receptor by morphine results in a euphoric phenotype, thus conferring the reinforcing effects of the drug. This activation is accompanied by extracellular dopamine release, which alters several events related to the cAMP signal transduction pathway. Of particular significance is that CREB seems to be modified by morphine, thereby affecting addictive behavioral phenomena, such as withdrawal symptoms.
- IHC, ICC, ELISA
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Reconstitution and Storage:
- Add 100ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Printable datasheet for AMM00043
- Mouse IgG
- Target Reference:
- Muller, A., et al., 2008, PLoS ONE. 3(2): e1641.
Glattard, E., et al., 2010, PLoS One, 5(1): e8791.
Laux, A, et. al. J Comp Neurol. 2011 Nov 18. PubMed PMID: 22102217.
Charron, G, et. al. Brain. 2011 Aug; 134(Pt 8): 2321-38.
Laux, A, et. al. J Comp Neurol. 2011 Aug 15;519(12):2390-416.