- Description of Target:
- Morphine is thought to produce reinforcement phenomena via stimulation of mu, delta, and kappa opioid receptors that regulate stress perception, pain control, reward behavior, and neurohormone secretion in reward-relevant brain systems. It has the highest affinity for mu, followed by delta and kappa. Rapid activation of the mu opioid receptor by morphine results in a euphoric phenotype, thus conferring the reinforcing effects of the drug. This activation is accompanied by extracellular dopamine release, which alters several events related to the cAMP signal transduction pathway. Of particular significance is that CREB seems to be modified by morphine, thereby affecting addictive behavioral phenomena, such as withdrawal symptoms.
- ELISA, IHC, ICC, CHIP
- Tested Species Reactivity:
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Printable datasheet for AMM00033
- Mouse IgG
Charlet, A. et al. Abnormal nociception and opiate sensitivity of STOP null mice exhibiting elevated levels of the endogenous alkaloid morphine. Mol. Pain 6, 96 (2010). ELISA, IHC, ICC, CHIP, 21172011
Glattard, E. et al. Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils. PLoS One 5, e8791 (2010). ELISA, IHC, ICC, CHIP, 20098709
Laux, A. et al. Localization of endogenous morphine-like compounds in the mouse spinal cord. J. Comp. Neurol. 520, 1547-61 (2012). ELISA, IHC, ICC, CHIP, 22102217
Laux, A. et al. Mapping of endogenous morphine-like compounds in the adult mouse brain: Evidence of their localization in astrocytes and GABAergic cells. J. Comp. Neurol. 519, 2390-416 (2011). ELISA, IHC, ICC, CHIP, 21456021
- Target Reference:
- Muller, A., et al., 2008, PLoS ONE. 3(2): e1641.
Glattard, E., et al., 2010, PLoS One, 5(1): e8791.