MMP14 Recombinant Protein (Human) (OPED00095)

Catalog No: OPED00095

Size:10UG

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Liquid. In 50mM TRIS, pH 7.5, containing 5mM calcium chloride, 300mM sodium chloride, 20 uM zinc chloride, 0.5% Brij-35, and 30% glycerol.
• Host: E. Coli
• Reconstitution and Storage: Store at -80C
• Purification: Partially purified by single-step affinity chromatography and gel filtration.
• Biological Activity: ≥70 U/µg. One U=100 pmol/min at 37°C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-LeuGly-OEt (100 µM) as substrate
• Application Info: Useful tool to study enzyme kinetics, cleave target substrates, and screen for inhibitors.

Target Info

• Gene Symbol: MMP14
• Gene Full Name: matrix metallopeptidase 14
• Alias Symbols: matrix metallopeptidase 14 (membrane-inserted);matrix metalloproteinase-14;membrane type 1 metalloprotease;Membrane-type matrix metalloproteinase 1;membrane-type-1 matrix metalloproteinase;MMP-14;MMP-X1;MT1MMP;MT1-MMP;MT-MMP;MT-MMP 1;MTMMP1;WNCHRS.
• NCBI Gene Id: 4323
• Protein Name: Matrix metalloproteinase-14
• Description of Target: Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).
• Uniprot ID: P50281
• Protein Size (# AA): Recombinant
• Molecular Weight: 65 kD