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Catalog No: OPED00092
Size:10 ug
Price: $349.00
Availability: Domestic: within 1 week delivery | International: 1 week
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Datasheets/ManualsPrintable datasheet for OPED00092
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. In 50mM TRIS, 5mM CaCl2, 300mM NaCl, 20 uM ZnCl2, 0.5% Brij-35, and 30% glycerol.
HostE. Coli
Additional InformationMMP-11 may be a link between obesity and cancer.
Reconstitution and StorageStore at -80C
PurificationPurified by multi-step chromatography.
Purity>95% (SDS-PAGE)
Application InfoUseful to study enzyme kinetics, cleave target substrates, and screen for inhibitors.
ReferenceCancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle: E.R. Motrescu & M.C. Rio; Biol. Chem. 389, 1037 (2008), Abstract;
Gene SymbolMMP11
Gene Full Namematrix metallopeptidase 11
Alias SymbolsST3, SL-3, STMY3
NCBI Gene Id4320
Protein NameStromelysin-3
Description of TargetProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
Uniprot IDP24347
Protein Accession #NP_003833.4
Nucleotide Accession #NM_003842.4
Protein Size (# AA)488
Molecular Weight19 kDa
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