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Catalog No: OOMC00015
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OOMC00015
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Datasheets/ManualsPrintable datasheet for OOMC00015
Product Info
Product FormatLyophilized
Additional InformationCAS: 905579-51-3
Molecular Formula: C21H25N5O4S
::Chemical Name: ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate
::Primary Activity: Nedd8 activating enzyme inhibitor
::COVID-19 Rationale: Targets Cullin2, which interacts with SARS-CoV-2 Orf10
Reconstitution and StorageSoluble in DMSO (up to 10 mg/ml). Store at -20C.
Purity> 98%
Reference1) Soucy, et al. (2009), An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 458 732 2) Milhollen, et al., (2010) MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-(kappa)B-dependent lymphoma. Blood. 116 1515 3) Zhou et al. (2019) Neddylation inhibition upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma; Int. J. Cancer, 145 763 4) Zhou et al. (2019) Neddylation: a novel modulator of the tumor microenvironment; Mol. Cancer 18 77
Molecular Weight443.53 g/mol
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