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- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
| Datasheets/Manuals | Printable datasheet for OAAF08320 |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Product Format | Liquid. Supplied in 1% BSA, 0.05M Tris-HCl, 0.15M NaCl, 0.2% Kathon CG/ICP, 0.1% Tween-20 |
| Clonality | Monoclonal |
| Clone | ABT-MLH1 |
| Isotype | IgG |
| Host | Mouse |
| Application | WB, IHC-P |
| Additional Information | Retrieval buffer: Citrate buffer of pH6.0 |
| :: | Description: Mouse monoclonal to MutL Protein Homolog 1 (MLH1) |
| Reconstitution and Storage | Shipped at 4C. Store at -20C. Stable for 12 months at -20C. |
| Immunogen | The antiserum was produced against synthesized peptide derived between 460-500 aa of human MLH1. The exact sequence is proprietary. |
| Purification | Immunogen affinity purified |
| Specificity | Anti-MutL Protein Homolog 1 (MLH1) [ABT-MLH1] detects endogenous levels of total MutL Protein Homolog 1 (MLH1) protein. |
| Application Info | IHC 1:200 - 1:400, WB 1:100 - 1:500 |
| Gene Symbol | MLH1 |
|---|---|
| Gene Full Name | mutL homolog 1 |
| Alias Symbols | FCC2, COCA2, HNPCC, hMLH1, HNPCC2, MMRCS1 |
| NCBI Gene Id | 4292 |
| Protein Name | DNA mismatch repair protein Mlh1 |
| Description of Target | The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). |
| Uniprot ID | P40692 |
| Protein Accession # | NP_000240.1 |
| Nucleotide Accession # | NM_000249.3 |
| Molecular Weight | 84 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "MLH1 Antibody (OAAF08320)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "".
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How long will it take to receive "MLH1 Antibody (OAAF08320)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
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What buffer format is "MLH1 Antibody (OAAF08320)" provided in?
This item is provided in "Liquid. Supplied in 1% BSA, 0.05M Tris-HCl, 0.15M NaCl, 0.2% Kathon CG/ICP, 0.1% Tween-20".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "MLH1 Antibody (OAAF08320)"?
This target may also be called "FCC2, COCA2, HNPCC, hMLH1, HNPCC2, MMRCS1" in publications.
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What is the shipping cost for "MLH1 Antibody (OAAF08320)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "MLH1 Antibody (OAAF08320)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "MLH1 Antibody (OAAF08320)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "84 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "MLH1 Antibody (OAAF08320)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "MLH1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "MLH1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "MLH1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "MLH1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "MLH1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "MLH1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
