MKI67 Antibody (OAAJ07292)

Catalog No: OAAJ07292

Size:100 uL

Western blot analysis of extracts of HeLacell lines, using MKI67 antibody.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles.
• Immunogen: Recombinant proteinof human MKI67
• Purification: Immunogen affinity chromatography
• Concentration: 1 mg/mL

Target Info

• Gene Symbol: MKI67
• Alias Symbols: KIA, MIB-, MIB-1, PPP1R105
• NCBI Gene Id: 4288
• Protein Name: Proliferation marker protein Ki-67
• Description of Target: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes . May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
• Uniprot ID: P46013
• Protein Accession #: NP_001139438
• Nucleotide Accession #: NM_001145966
• Molecular Weight: 359 kDa