MITF Antibody (Phospho-Ser180) (OASG04548)

Catalog No: OASG04548

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Monkey
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human MITF around the phosphorylation site of S180. Location: 120-200aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Ser180
• Specificity: Phospho-MITF (S180) Polyclonal Antibody detects endogenous levels of MITF protein only when phosphorylated at S180.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Target Info

• Gene Symbol: MITF
• Gene Full Name: microphthalmia-associated transcription factor
• Alias Symbols: MI, WS2, CMM8, WS2A, COMMAD, bHLHe32
• NCBI Gene Id: 4286; 17342;
• Description of Target: This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Uniprot ID: O75030, Q08874
• Molecular Weight: 52 kDa