MID1 Antibody - N-terminal region (ARP58031_P050)

Catalog No: ARP58031_P050

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Host: Rabbit
Target Name: MID1
Sample Type: Transfected 293T Whole Cell lysates
Antibody Dilution: 1.0ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MID1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 85%
• Peptide Sequence: Synthetic peptide located within the following region: PTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAF
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-MID1 (ARP58031_P050) antibody is Catalog # AAP58031

Target Info

• Gene Symbol: MID1
• Gene Full Name: midline 1 (Opitz/BBB syndrome)
• Alias Symbols: OS, FXY, OSX, OGS1, XPRF, BBBG1, GBBB1, MIDIN, RNF59, ZNFXY, TRIM18
• NCBI Gene Id: 4281
• Protein Name: Midline-1
• Description of Target: The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse.
• Uniprot ID: O15344-2
• Protein Size (# AA): 552
• Molecular Weight: 60kDa
• Protein Interactions: STK36; MID2; UBE2E3; DYRK4; UBE2E2; UBE2E1; UBE2D3; UBE2D2; UBE2D1; PKN1; PPP2R4; PPP2CA; MID1; MEOX1; FKBP1A; EHHADH; BYSL; TCEANC; UBTD1; OTUB2; GMCL1; HTT; IGBP1; PNKP; MID1IP1; GNB2L1; RPS8; RPS3; NPM1; HSP90AA1; EEF1A1; ANXA2; UBC; UBE2D4; UBE2N; ELA