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MICA Antibody - middle region (OAAB05218)

400ul
$390.00
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Gene Symbol:
MICA
NCBI Gene Id:
4276
Protein Name:
MHC class I polypeptide-related sequence A
Swissprot Id:
Q29983
Protein Accession #:
NP_000238.1
Alias Symbols:
MHC class I polypeptide-related sequence A, MIC-A, MICA
Replacement Item:
This antibody may replace item sc-137242 from Santa Cruz Biotechnology.
Description of Target:
MICA is the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.
Molecular Weight:
43 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Application:
WB, IHC-P, IF, FC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MICA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MICA.
Immunogen:
This MICA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-97 amino acids from the Central region of human MICA.
Predicted Species Reactivity:
Human
Product Format:
Liquid. PBS with 0.09% (W/V) sodium azide.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
0.5 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-MICA antibody - OAAB05218
Isotype:
Rabbit Ig
Intended Use:
For research use only and not for use in diagnostic or therapeutic procedures.
Application Info:
IF: 1:25
FC: 1:25
IHC-P: 1:25
:::
Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T- cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Cellular Location: Cell membrane; Single- pass type I membrane protein Cytoplasm Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum
Tissue Location: Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.

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